Amoxicillin and clavulanic acid, commonly known by the brand name Augmentin, are antibiotics used to treat a wide range of bacterial infections. The 875mg/125mg dosage of this combination is a potent form used to combat infections that are more severe or resistant to standard antibiotics. In this article, we will delve into the dosing regimen, its uses, potential side effects, and other important information about this medication.

Understanding the Ingredients

Amoxicillin: Amoxicillin is a penicillin-like antibiotic that is effective against various bacterial infections. It works by inhibiting the growth and multiplication of bacteria, thus aiding the body’s immune system in fighting off the infection.

Clavulanic Acid: Clavulanic acid is often added to amoxicillin to extend its spectrum of action. It is a beta-lactamase inhibitor that helps prevent bacteria from developing resistance to amoxicillin. This combination is particularly effective against beta-lactamase-producing bacteria, which are resistant to many antibiotics.

The 875mg/125mg Dosage

The Amoxicillin/Clavulanic Acid 875mg/125mg dosage is a relatively high strength, reserved for infections that require a more potent treatment. The numbers denote the amount of each active ingredient in a single tablet. The 875mg of amoxicillin provides a higher concentration of the antibiotic, making it suitable for more severe infections, while the 125mg of clavulanic acid ensures that the medication remains effective against bacteria that produce beta-lactamase.

Dosing Instructions

The dosing regimen for this medication is determined by the specific infection being treated and the patient’s medical condition. Always follow your healthcare provider’s instructions or the information provided on the medication label.

Typically, the standard dosing is one 875mg/125mg tablet taken every 12 hours. This means that the patient will take two tablets daily. It’s essential to space these doses evenly, such as one tablet in the morning and one in the evening.

This medication can be taken with or without food. However, taking it with a meal can help reduce the likelihood of stomach upset.

Uses of Amoxicillin/Clavulanic Acid 875mg/125mg

Respiratory Infections: This dosage is commonly prescribed for severe respiratory infections, such as pneumonia and bronchitis.

Skin and Soft Tissue Infections: It is effective in treating skin and soft tissue infections, including cellulitis and abscesses.

Urinary Tract Infections: In cases of complicated urinary tract infections, this dosage can be used to combat the infection.

Sinus Infections: Severe sinus infections that do not respond to milder antibiotics may require the use of Amoxicillin/Clavulanic Acid 875mg/125mg.

Otitis Media: This medication can also be prescribed for acute otitis media, an ear infection that typically affects children.

It’s important to note that this medication should only be taken when prescribed by a healthcare professional. Self-medication or the use of leftover antibiotics is not recommended, as it can lead to antibiotic resistance and ineffective treatment.

Potential Side Effects

As with any medication, Amoxicillin/Clavulanic Acid 875mg/125mg can have potential side effects. Common side effects may include:

Upset stomach or diarrhea: Taking the medication with food can help alleviate this.

Nausea and vomiting: If you experience severe or persistent vomiting, contact your healthcare provider.

Skin rash or itching: Allergic reactions are possible, and if you notice any signs of an allergic reaction, such as hives, swelling, or difficulty breathing, seek immediate medical attention.

Headache: Some individuals may experience headaches as a side effect.

Yeast infections: The use of antibiotics can disrupt the natural balance of microorganisms in the body, potentially leading to yeast infections.

In rare cases, this medication can cause more severe side effects, including severe diarrhea, liver problems, or blood disorders. If you experience any unusual or severe symptoms, it’s crucial to contact your healthcare provider promptly.

Precautions and Contraindications

Allergies: Inform your healthcare provider if you are allergic to amoxicillin, clavulanic acid, or any other penicillin-like antibiotics.

Medical Conditions: If you have a history of liver disease, kidney disease, or any other medical conditions, discuss them with your healthcare provider before starting this medication.

Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the potential risks and benefits of using this medication with your healthcare provider.

Drug Interactions: Inform your healthcare provider of any other medications or supplements you are taking, as there may be interactions that could affect the effectiveness or safety of Amoxicillin/Clavulanic Acid.


Amoxicillin/Clavulanic Acid 875mg/125mg is a powerful antibiotic combination used to treat severe bacterial infections. Proper dosing and adherence to healthcare provider recommendations are essential to ensure effective treatment and minimize the risk of side effects. This medication should always be taken under the guidance of a medical professional to address bacterial infections effectively while minimizing the risk of antibiotic resistance. If you experience any unexpected side effects, consult your healthcare provider promptly for guidance and potential adjustments to your treatment plan.


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